Mutation in Irf8 Gene (Irf8R294C) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs

Mutation in Irf8 Gene (Irf8R294C) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs

Plasmacytoid dendritic cells (pDCs) are the key producers of type I interferons (IFNs), thus playing a central role in initiating antiviral immune response. Besides robust type I IFN production, pDCs also act as antigen presenting cells post immunogenic stimulation. Transcription factor Irf8 is indi...

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Bibliographic Details
Main Authors: Annesa Das, Kuldeep Singh Chauhan, Himanshu Kumar, Prafullakumar Tailor
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
plasmacytoid dendritic cells (pDCs)
type I interferons (IFNs)
IRF8R294C
antiviral immune response
interferon regulatory factor 8 (IRF8)
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.758190/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.758190/full

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