Botulinum Toxin Treatment of Adult Muscle Stem Cells from Children with Cerebral Palsy and hiPSC-Derived Neuromuscular Junctions

Botulinum Toxin Treatment of Adult Muscle Stem Cells from Children with Cerebral Palsy and hiPSC-Derived Neuromuscular Junctions

Botulinum neurotoxin type-A (BoNT) injections are commonly used as spasticity treatment in cerebral palsy (CP). Despite improved clinical outcomes, concerns regarding harmful effects on muscle morphology have been raised, and the BoNT effect on muscle stem cells remains not well defined. This study...

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Bibliographic Details
Main Authors: Domiziana Costamagna, Valeria Bastianini, Marlies Corvelyn, Robin Duelen, Jorieke Deschrevel, Nathalie De Beukelaer, Hannah De Houwer, Maurilio Sampaolesi, Ghislaine Gayan-Ramirez, Anja Van Campenhout, Kaat Desloovere
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
cerebral palsy in young children
BoNT cell treatment
muscle microbiopsy
adult muscle stem cells
induced pluripotent stem cells
myogenesis
Online Access:https://www.mdpi.com/2073-4409/12/16/2072

Internet

https://www.mdpi.com/2073-4409/12/16/2072

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