LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells

LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells

Upon implantation, the trophectoderm differentiates into the multi-nucleated primitive syncytiotrophoblast (pSTB) through a process called primary syncytialization to facilitate maternal-fetal interactions and to establish a pregnancy. However, ethical issues and limited access to human embryos arou...

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Bibliographic Details
Main Authors: Yiming Wang, Hao Wu, Xiangxiang Jiang, Lei Jia, Meijiao Wang, Yin Rong, Shuo Chen, Yue Wang, Zhenyu Xiao, Xiaoyan Liang, Hongmei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
human trophoblast stem cell
primary syncytialization
nuclear enlargement
lamin A
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.836390/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.836390/full

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