Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway

Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway

Abstract Background The natural compound asperosaponin VI has shown potential as an antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to chronic mild stress (CMS) and the underlying molecular pathways. Methods Mice were exposed to CMS for 3 weeks followed by...

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Bibliographic Details
Main Authors: Xue Jiang, Saini Yi, Qin Liu, Dapeng Su, Liangyuan Li, Chenghong Xiao, Jinqiang Zhang
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Neuroinflammation
Subjects:
Asperosaponin VI
Depression
Microglia
Hippocampus
PPAR-γ
Neuroinflammatory
Online Access:https://doi.org/10.1186/s12974-022-02478-y

Internet

https://doi.org/10.1186/s12974-022-02478-y

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