Transformation of a Metal Chelate into a “Catch and Anchor” Inhibitor of Botulinum A Protease

Transformation of a Metal Chelate into a “Catch and Anchor” Inhibitor of Botulinum A Protease

Targeting the botulinum neurotoxin light chain (LC) metalloprotease using small-molecule metal chelate inhibitors is a promising approach to counter the effects of the lethal toxin. However, to overcome the pitfalls associated with simple reversible metal chelate inhibitors, it is crucial to investi...

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Bibliographic Details
Main Authors: Lucy Lin, Ealin N. Patel, Alexander L. Nielsen, Lewis D. Turner, William H. Tepp, Kong Nguyen, Sabine Pellett, Kim Janda
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
botulinum neurotoxin
catch and anchor inhibition
covalent inhibitors
structure-based drug design
Online Access:https://www.mdpi.com/1422-0067/24/5/4303

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https://www.mdpi.com/1422-0067/24/5/4303

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