Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage

Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage

Metabolism of anabolic androgenic steroids is important for its physiological effects. The aim was to investigate the effects of finasteride (a 5α-reductase inhibitor - 5αR) on cardiac and mutagenic effects promoted by ND. Male Wistar rats were separated into three groups: CONT, received the vehicle...

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Bibliographic Details
Main Authors: Elizângela Faustino Da Mata, Andrews Marques do Nascimento, Ewelyne Miranda de Lima, Ieda Carneiro Kalil, Denise Coutinho Endringer, Dominik Lenz, Nazaré Souza Bissoli, Girlandia Alexandre Brasil, Tadeu Uggere de Andrade
Format: Article
Language:English
Published: Universidade de São Paulo 2020-03-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Dehydronandrolone
Finasteride
Mutagenicity
Cardiac Hypertrophy
Anabolic Androgenic Steroids
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100532&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100532&tlng=en

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