Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity

Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity

The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II diabetes. Therapeutic interventions targeting IAPP amyloidogenesis, which contributes to pancreatic β-cell degeneration,...

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Bibliographic Details
Main Authors: Mathilde Fortier, Mélanie Côté-Cyr, Vy Nguyen, Margaryta Babych, Phuong Trang Nguyen, Roger Gaudreault, Steve Bourgault
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
islet amyloid polypeptide
self-assembly
amyloid fibrils
cytotoxicity
molecular dynamics simulation
conformation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1017336/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1017336/full

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