Optical Genome Mapping Reveals Genomic Alterations upon Gene Editing in hiPSCs: Implications for Neural Tissue Differentiation and Brain Organoid Research

Optical Genome Mapping Reveals Genomic Alterations upon Gene Editing in hiPSCs: Implications for Neural Tissue Differentiation and Brain Organoid Research

Genome editing, notably CRISPR (cluster regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9), has revolutionized genetic engineering allowing for precise targeted modifications. This technique’s combination with human induced pluripotent stem cells (hiPSCs) is a partic...

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Bibliographic Details
Main Authors: Lucia Gallego Villarejo, Wanda M. Gerding, Lisa Bachmann, Luzie H. I. Hardt, Stefan Bormann, Huu Phuc Nguyen, Thorsten Müller
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cells
Subjects:
optical genome mapping
human induced pluripotent stem cells (hiPSC)
cerebral organoids
CRISPR
gene editing
structural variants (SVs)
Online Access:https://www.mdpi.com/2073-4409/13/6/507

Internet

https://www.mdpi.com/2073-4409/13/6/507

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