Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma

Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma

Therapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated ste...

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Bibliographic Details
Main Authors: Monika Sharma, Ivana Barravecchia, Brian Magnuson, Sarah F. Ferris, April Apfelbaum, Nneka E. Mbah, Jeanette Cruz, Varunkumar Krishnamoorthy, Robert Teis, McKenzie Kauss, Carl Koschmann, Costas A. Lyssiotis, Mats Ljungman, Stefanie Galban
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Diffuse midline glioma (DMG)
Cancer stem cells
H3K27M
Resistance
Radiosensitization
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558623000556

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http://www.sciencedirect.com/science/article/pii/S1476558623000556

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