Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment
Regulatory T cells (Tregs), which execute their immunosuppressive functions by multiple mechanisms, have been verified to contribute to the tumor microenvironment (TME). Numerous studies have shown that the activation of the CBM complex/NF-κB signaling pathway results in the expression of hypoxia-in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.911811/full |
| _version_ | 1818195902523768832 |
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| author | Tongbing Qi Tongbing Qi Ying Luo Weitong Cui Yue Zhou Xuan Ma Dongming Wang Xuewen Tian Qinglu Wang Qinglu Wang |
| author_facet | Tongbing Qi Tongbing Qi Ying Luo Weitong Cui Yue Zhou Xuan Ma Dongming Wang Xuewen Tian Qinglu Wang Qinglu Wang |
| author_sort | Tongbing Qi |
| collection | DOAJ |
| description | Regulatory T cells (Tregs), which execute their immunosuppressive functions by multiple mechanisms, have been verified to contribute to the tumor microenvironment (TME). Numerous studies have shown that the activation of the CBM complex/NF-κB signaling pathway results in the expression of hypoxia-inducible factor-1 (HIF-1α) and interleukin-6 (IL-6), which initiate the TME formation. HIF-1α and IL-6 promote regulatory T cells (Tregs) proliferation and migration through the MAPK/CDK4/6/Rb and STAT3/SIAH2/P27 signaling pathways, respectively. IL-6 also promotes the production of HIF-1α and enhances the self-regulation of Tregs in the process of tumor microenvironment (TME) formation. In this review, we discuss how the crosstalk between the CARMA1–BCL10–MALT1 signalosome complex (CBM complex)/NF-κB and MAPK/P27 signaling pathways contributes to the formation of the TME, which may provide evidence for potential therapeutic targets in the treatment of solid tumors. |
| first_indexed | 2024-12-12T01:25:34Z |
| format | Article |
| id | doaj.art-fff4b6ee87bb4286be031a0a57d1c4c8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T01:25:34Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-fff4b6ee87bb4286be031a0a57d1c4c82022-12-22T00:43:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-07-011010.3389/fcell.2022.911811911811Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironmentTongbing Qi0Tongbing Qi1Ying Luo2Weitong Cui3Yue Zhou4Xuan Ma5Dongming Wang6Xuewen Tian7Qinglu Wang8Qinglu Wang9College of Sport and Health, Shandong Sport University, Jinan, ChinaKey Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, Zibo, ChinaClinical Laboratory, Zibo Central Hospital, Zibo, ChinaKey Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, Zibo, ChinaKey Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, Zibo, ChinaKey Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, Zibo, ChinaDepartment of Pediatrics, People’s Hospital of Huantai, Zibo, ChinaCollege of Sport and Health, Shandong Sport University, Jinan, ChinaCollege of Sport and Health, Shandong Sport University, Jinan, ChinaKey Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, Zibo, ChinaRegulatory T cells (Tregs), which execute their immunosuppressive functions by multiple mechanisms, have been verified to contribute to the tumor microenvironment (TME). Numerous studies have shown that the activation of the CBM complex/NF-κB signaling pathway results in the expression of hypoxia-inducible factor-1 (HIF-1α) and interleukin-6 (IL-6), which initiate the TME formation. HIF-1α and IL-6 promote regulatory T cells (Tregs) proliferation and migration through the MAPK/CDK4/6/Rb and STAT3/SIAH2/P27 signaling pathways, respectively. IL-6 also promotes the production of HIF-1α and enhances the self-regulation of Tregs in the process of tumor microenvironment (TME) formation. In this review, we discuss how the crosstalk between the CARMA1–BCL10–MALT1 signalosome complex (CBM complex)/NF-κB and MAPK/P27 signaling pathways contributes to the formation of the TME, which may provide evidence for potential therapeutic targets in the treatment of solid tumors.https://www.frontiersin.org/articles/10.3389/fcell.2022.911811/fullregulatory T cellstumor microenvironmentCBM signaling pathwayMAPK/P27 signaling pathwayCARMA1 |
| spellingShingle | Tongbing Qi Tongbing Qi Ying Luo Weitong Cui Yue Zhou Xuan Ma Dongming Wang Xuewen Tian Qinglu Wang Qinglu Wang Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment Frontiers in Cell and Developmental Biology regulatory T cells tumor microenvironment CBM signaling pathway MAPK/P27 signaling pathway CARMA1 |
| title | Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment |
| title_full | Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment |
| title_fullStr | Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment |
| title_full_unstemmed | Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment |
| title_short | Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment |
| title_sort | crosstalk between the cbm complex nf κb and mapk p27 signaling pathways of regulatory t cells contributes to the tumor microenvironment |
| topic | regulatory T cells tumor microenvironment CBM signaling pathway MAPK/P27 signaling pathway CARMA1 |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.911811/full |
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