Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome

Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome

BackgroundUnlike arteries, in which regionally distinct hemodynamics are associated with phenotypic heterogeneity, the relationships between endocardial endothelial cell phenotype and intraventricular flow remain largely unexplored. We investigated regional differences in left ventricular wall shear...

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Bibliographic Details
Main Authors: Margaret E. McCormick, Elisabetta Manduchi, Walter R. T. Witschey, Robert C. Gorman, Joseph H. Gorman, Yi‐Zhou Jiang, Christian J. Stoeckert, Alex J. Barker, Michael Markl, Peter F. Davies
Format: Article
Language:English
Published: Wiley 2016-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
4‐dimensional flow magnetic resonance imaging
endocardium
gene expression
hemodynamics
ventricle
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.003170

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.115.003170

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