The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation. The prototypical and homonymous family member is an Escherichia coli “adaptive response” protein tha...

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Bibliographic Details
Main Authors: Fedeles, Bogdan I., Singh, Vipender, Delaney, James C., Li, Deyu, Essigmann, John M.
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Society for Biochemistry and Molecular Biology (ASBMB) 2015
Online Access:http://hdl.handle.net/1721.1/100429
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-8241-4834
https://orcid.org/0000-0002-2196-5691