Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

Dysregulation of ErbB-family signaling underlies numerous pathologies and has been therapeutically targeted through inhibiting ErbB-receptors themselves or their cognate ligands. For the latter, “decoy” antibodies have been developed to sequester ligands including heparin-binding epidermal growth fa...

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Bibliographic Details
Main Authors: Miller, Miles Aaron, Moss, Marcia L., Powell, Gary, Petrovich, Robert, Edwards, Lori, Griffith, Linda G., Lauffenburger, Douglas A., Meyer, Aaron Samuel
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/100525
https://orcid.org/0000-0002-1801-5548

Internet

http://hdl.handle.net/1721.1/100525
https://orcid.org/0000-0002-1801-5548

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