Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor

Optimizing bio-production involves strain and process improvements performed as discrete steps. However, environment impacts genotype and a strain that is optimal under one set of conditions may not be under different conditions. We present a methodology to simultaneously vary genetic and process fa...

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Bibliographic Details
Main Authors: Zhou, Hui, Vonk, Brenda, Roubos, Johannes A., Voigt, Christopher A., Bovenberg, Roel A. L.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Oxford University Press 2016
Online Access:http://hdl.handle.net/1721.1/100578
https://orcid.org/0000-0003-0844-4776