Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

Background Viruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which natural killer (NK) cells recognize HIV-1-infected cells and how this virus can evade NK-cell-mediated immune pressure. Methods and F...

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Bibliographic Details
Main Authors: Thobakgale, Christina F., Jimenez Cruz, Camilo A., Garcia-Beltran, Wilfredo F., Carlson, Jonathan M., van Teijlingen, Nienke H., Mann, Jaclyn K., Jaggernath, Manjeetha, Kang, Seung-gu, Chung, Amy W., Schafer, Jamie L., Evans, David T., Alter, Galit, Walker, Bruce D., Goulder, Philip J., Carrington, Mary, Hartmann, Pia, Pertel, Thomas, Zhou, Ruhong, Ndung'u, Thumbi, Altfeld, Marcus, Holzemer, Angelique, Korner, Christian
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2016
Online Access:http://hdl.handle.net/1721.1/100696
https://orcid.org/0000-0003-1570-9445

Internet

http://hdl.handle.net/1721.1/100696
https://orcid.org/0000-0003-1570-9445

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