Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions

Although only 5% of the human genome is conserved across mammals, a substantially larger portion is biochemically active, raising the question of whether the additional elements evolve neutrally or confer a lineage-specific fitness advantage. To address this question, we integrate human variation in...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Ward, Lucas D., Kellis, Manolis
Бусад зохиолчид: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Формат: Өгүүллэг
Хэл сонгох:en_US
Хэвлэсэн: American Association for the Advancement of Science (AAAS) 2016
Онлайн хандалт:http://hdl.handle.net/1721.1/100727
https://orcid.org/0000-0002-8017-809X