Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
Alzheimer’s disease (AD) is a severe age-related neurodegenerative disorder characterized by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during neurodegener...
Main Authors: | Gjoneska, Elizabeta, Pfenning, Andreas R., Mathys, Hansruedi, Quon, Gerald, Kundaje, Anshul, Tsai, Li-Huei, Kellis, Manolis |
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Other Authors: | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
Format: | Article |
Language: | en_US |
Published: |
American Association for the Advancement of Science (AAAS)
2016
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Online Access: | http://hdl.handle.net/1721.1/100729 https://orcid.org/0000-0002-3447-9801 https://orcid.org/0000-0003-1262-0592 https://orcid.org/0000-0002-1716-0153 https://orcid.org/0000-0002-3255-4740 https://orcid.org/0000-0001-5842-5245 |
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