Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

Little is known about how mitotic cells round against epithelial confinement. Here, we engineer micropillar arrays that subject cells to lateral mechanical confinement similar to that experienced in epithelia. If generating sufficient force to deform the pillars, rounding epithelial (MDCK) cells can...

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Bibliographic Details
Main Authors: Sorce, Barbara, Escobedo, Carlos, Toyoda, Yusuke, Cattin, Cedric J., Newton, Richard, Banerjee, Indranil, Stettler, Alexander, Roska, Botond, Eaton, Suzanne, Hyman, Anthony A., Hierlemann, Andreas, Muller, Daniel J., Stewart, Martin P
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2016
Online Access:http://hdl.handle.net/1721.1/100828
https://orcid.org/0000-0003-4112-6622

Internet

http://hdl.handle.net/1721.1/100828
https://orcid.org/0000-0003-4112-6622

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