Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
Current antibiotics tend to be broad spectrum, leading to indiscriminate killing of commensal bacteria and accelerated evolution of drug resistance. Here, we use CRISPR-Cas technology to create antimicrobials whose spectrum of activity is chosen by design. RNA-guided nucleases (RGNs) targeting speci...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2016
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| Online Access: | http://hdl.handle.net/1721.1/100834 https://orcid.org/0000-0002-9999-6690 https://orcid.org/0000-0002-3083-2671 https://orcid.org/0000-0002-6397-5417 |