Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

Using a new bioinformatic method to analyze ribosome profiling data, we show that 40% of lncRNAs and pseudogene RNAs expressed in human cells are translated. In addition, ~35% of mRNA coding genes are translated upstream of the primary protein-coding region (uORFs) and 4% are translated downstream (...

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Bibliographic Details
Main Authors: Ji, Zhe, Song, Ruisheng, Regev, Aviv, Struhl, Kevin
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: eLife Sciences Publications, Ltd. 2016
Online Access:http://hdl.handle.net/1721.1/101022
https://orcid.org/0000-0001-8567-2049