Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins
Using a new bioinformatic method to analyze ribosome profiling data, we show that 40% of lncRNAs and pseudogene RNAs expressed in human cells are translated. In addition, ~35% of mRNA coding genes are translated upstream of the primary protein-coding region (uORFs) and 4% are translated downstream (...
Main Authors: | Ji, Zhe, Song, Ruisheng, Regev, Aviv, Struhl, Kevin |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
eLife Sciences Publications, Ltd.
2016
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Online Access: | http://hdl.handle.net/1721.1/101022 https://orcid.org/0000-0001-8567-2049 |
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