Substrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance

Substrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance

The rapid evolution of HIV under selective drug pressure has led to multidrug resistant (MDR) strains that evade standard therapies. We designed highly potent HIV-1 protease inhibitors (PIs) using the substrate envelope model, which confines inhibitors within the consensus volume of natural substrat...

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Bibliographic Details
Main Authors: Nalam, Madhavi N. L., Ali, Akbar, Reddy, G.S. Kiran Kumar, Cao, Hong, Anjum, Saima G., Altman, Michael D., Yilmaz, Nese Kurt, Tidor, Bruce, Rana, Tariq M., Schiffer, Celia A.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101077
https://orcid.org/0000-0002-3320-3969

Internet

http://hdl.handle.net/1721.1/101077
https://orcid.org/0000-0002-3320-3969

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