Exploring the gap between dynamic and constraint-based models of metabolism

Systems biology provides new approaches for metabolic engineering through the development of models and methods for simulation and optimization of microbial metabolism. Here we explore the relationship between two modeling frameworks in common use namely, dynamic models with kinetic rate laws and co...

Full description

Bibliographic Details
Main Authors: Machado, Daniel, Costa, Rafael S., Rocha, Isabel, Tidor, Bruce, Ferreira, Eugenio C.
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101078
https://orcid.org/0000-0002-3320-3969