In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

Objectives The aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macrophages improves infarct healing and attenuates post–myocardial infarction (MI) remodeling. Background In healing wounds, the M1 toward M2 macrophage phe...

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Bibliographic Details
Main Authors: Courties, Gabriel, Heidt, Timo, Sebas, Matthew, Iwamoto, Yoshiko, Jeon, Derrick, Truelove, Jessica, Tricot, Benoit, Wojtkiewicz, Greg, Dutta, Partha, Sager, Hendrik B., Borodovsky, Anna, Novobrantseva, Tatiana I., Klebanov, Boris, Fitzgerald, Kevin, Libby, Peter, Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias, Anderson, Daniel Griffith
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101129
https://orcid.org/0000-0001-5629-4798

Internet

http://hdl.handle.net/1721.1/101129
https://orcid.org/0000-0001-5629-4798

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