The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

T cell activation by antigens binding to the T cell receptor (TCR) must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells while avoiding autoimmunity. The Src family kinase Lck and the Syk family kinase ZAP-70 (ζ chain–associa...

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Bibliographic Details
Main Authors: Sjolin-Goodfellow, Hanna, Frushicheva, Maria P., Ji, Qinqin, Cheng, Debra A., Kadlecek, Theresa A., Cantor, Aaron J., Kuriyan, John, Salomon, Arthur R., Weiss, Arthur, Chakraborty, Arup K
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2016
Online Access:http://hdl.handle.net/1721.1/101165
https://orcid.org/0000-0002-7487-8858
https://orcid.org/0000-0003-1268-9602

Internet

http://hdl.handle.net/1721.1/101165
https://orcid.org/0000-0002-7487-8858
https://orcid.org/0000-0003-1268-9602

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