EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing

EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing

Glioblastomas (GBM) with EGFR amplification represent approximately 50% of newly diagnosed cases, and recent studies have revealed frequent coexistence of multiple EGFR aberrations within the same tumor, which has implications for mutation cooperation and treatment resistance. However, bulk tumor se...

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Bibliographic Details
Main Authors: Francis, Joshua M., Zhang, Cheng-Zhong, Maire, Cecile L., Jung, Joonil, Manzo, Veronica E., Homer, Heather, Haidar, Sam, Blumenstiel, Brendan, Pedamallu, Chandra Sekhar, Ligon, Azra H., Meyerson, Matthew L., Ligon, Keith L., Adalsteinsson, Viktor A., Love, John C
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: American Association for Cancer Research 2016
Online Access:http://hdl.handle.net/1721.1/101217
https://orcid.org/0000-0003-4555-2485
https://orcid.org/0000-0003-0921-3144

Internet

http://hdl.handle.net/1721.1/101217
https://orcid.org/0000-0003-4555-2485
https://orcid.org/0000-0003-0921-3144

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