In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

Hypoxic and VHL-deficient cells use glutamine to generate citrate and lipids through reductive carboxylation (RC) of α-ketoglutarate. To gain insights into the role of HIF and the molecular mechanisms underlying RC, we took advantage of a panel of disease-associated VHL mutants and showed that HIF e...

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Bibliographic Details
Main Authors: Gameiro, Paulo A., Yang, Juanjuan, Metelo, Ana M., Baker, Rania, Wang, Zongwei, Arreola, Alexandra, Rathmell, W. Kimryn, Olumi, Aria F., Stephanopoulos, Gregory, Iliopoulos, Othon, Perez-Carro, Rocio, Lopez-Larrubia, Pilar, Gameiro, Paulo A.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101235
https://orcid.org/0000-0001-6909-4568

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http://hdl.handle.net/1721.1/101235
https://orcid.org/0000-0001-6909-4568

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