Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

To use microRNAs to downregulate mRNA targets, cells must first process these ∼22 nt RNAs from primary transcripts (pri-miRNAs). These transcripts form RNA hairpins important for processing, but additional determinants must distinguish pri-miRNAs from the many other hairpin-containing transcripts ex...

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Bibliographic Details
Main Authors: Auyeung, Vincent C., Ulitsky, Igor, McGeary, Sean Edward, Bartel, David, Auyeung, Vincent C.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101253
https://orcid.org/0000-0002-3872-2856
https://orcid.org/0000-0001-5343-6447

Internet

http://hdl.handle.net/1721.1/101253
https://orcid.org/0000-0002-3872-2856
https://orcid.org/0000-0001-5343-6447

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