Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing
To use microRNAs to downregulate mRNA targets, cells must first process these ∼22 nt RNAs from primary transcripts (pri-miRNAs). These transcripts form RNA hairpins important for processing, but additional determinants must distinguish pri-miRNAs from the many other hairpin-containing transcripts ex...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/101253 https://orcid.org/0000-0002-3872-2856 https://orcid.org/0000-0001-5343-6447 |