High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

Although improvements in technology for the isolation of potential therapeutic antibodies have made the process increasingly predictable, the development of biologically active monoclonal antibodies (mAbs) into drugs can often be impeded by developability issues such as poor expression, solubility,...

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Bibliographic Details
Main Authors: Sun, Tingwan, Jain, Tushar, Caffry, Isabelle, Yu, Yao, Lynaugh, Heather, Brown, Michael, Xu, Yingda, Kelly, Ryan Lewis, Vasquez, Maximiliano, Wittrup, Karl Dane, Cao, Yuan,Ph. D.Massachusetts Institute of Technology.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Landes Bioscience 2016
Online Access:http://hdl.handle.net/1721.1/101373
https://orcid.org/0000-0003-2398-5896
https://orcid.org/0000-0001-5003-9104

Internet

http://hdl.handle.net/1721.1/101373
https://orcid.org/0000-0003-2398-5896
https://orcid.org/0000-0001-5003-9104

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