Targeted Cytolysins Synergistically Potentiate Cytoplasmic Delivery of Gelonin Immunotoxin

Targeted endocytic uptake is a first step toward tissue-specific cytoplasmic macromolecular delivery; however, inefficient escape from the endolysosomal compartment makes this generally impractical at present. We report here a targeted cytolysin approach that dramatically potentiates endosomal relea...

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Bibliographic Details
Main Authors: Wittrup, K. D., Pirie, Christopher M., Liu, David V., Wittrup, Karl Dane
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Association for Cancer Research 2016
Online Access:http://hdl.handle.net/1721.1/101380
https://orcid.org/0000-0003-2398-5896