Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli
Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, with specificity regulated by the binding of an effector to a distal allosteric s...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
eLife Sciences Publications, Ltd.
2016
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| Online Access: | http://hdl.handle.net/1721.1/101398 https://orcid.org/0000-0001-5486-2755 https://orcid.org/0000-0001-7362-9801 https://orcid.org/0000-0003-2117-3528 |