RGS9-2–controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states

RGS9-2–controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states

The striatal protein Regulator of G-protein signaling 9-2 (RGS9-2) plays a key modulatory role in opioid, monoamine, and other G-protein–coupled receptor responses. Here, we use the murine spared-nerve injury model of neuropathic pain to investigate the mechanism by which RGS9-2 in the nucleus accum...

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Bibliographic Details
Main Authors: Mitsi, Vasiliki, Terzi, Dimitra, Purushothaman, Immanuel, Manouras, Lefteris, Gaspari, Sevasti, Neve, Rachael L., Stratinaki, Maria, Feng, Jian, Shen, Li, Zachariou, Venetia
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2016
Online Access:http://hdl.handle.net/1721.1/101408
https://orcid.org/0000-0002-3854-5968

Internet

http://hdl.handle.net/1721.1/101408
https://orcid.org/0000-0002-3854-5968

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