Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there first has to be an available pool of intracellular am...

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Bibliographic Details
Main Authors: Carroll, Bernadette, Maetzel, Dorothea, Otten, Gisela, Ratcliff, Matthew, Jaenisch, Rudolf, Sarkar, Sovan, Maddocks, Oliver D. K., Smith, Graham R., Dunlop, Elaine A., Passos, Joao F., Davies, Owen R., Tee, Andrew R., Korolchuk, Viktor I.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: eLife Sciences Publications, Ltd. 2016
Online Access:http://hdl.handle.net/1721.1/101421

Internet

http://hdl.handle.net/1721.1/101421

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