Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity

Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity

Cancer therapy exerts a strong selection pressure that shapes tumor evolution, yet our knowledge of how tumors change during treatment is limited. Here, we report the analysis of cellular heterogeneity for genetic and phenotypic features and their spatial distribution in breast tumors pre- and post-...

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Bibliographic Details
Main Authors: Almendro, Vanessa, Cheng, Yu-Kang, Randles, Amanda, Itzkovitz, Shalev, Marusyk, Andriy, Ametller, Elisabet, Gonzalez-Farre, Xavier, Russnes, Hege G., Rye, Inga H., Borresen-Dale, Anne-Lise, Maruyama, Reo, van Oudenaarden, Alexander, Dowsett, Mitchell, Jones, Robin L., Reis-Filho, Jorge, Gascon, Pere, Michor, Franziska, Polyak, Kornelia, Munoz, Montse, Helland, Aslaug, Gonen, Mithat, van Oudenaarden, Alexander
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101428

Internet

http://hdl.handle.net/1721.1/101428

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