Structure–mechanics relationships of collagen fibrils in the osteogenesis imperfecta mouse model

Structure–mechanics relationships of collagen fibrils in the osteogenesis imperfecta mouse model

The collagen molecule, which is the building block of collagen fibrils, is a triple helix of two α1(I) chains and one α2(I) chain. However, in the severe mouse model of osteogenesis imperfecta (OIM), deletion of the COL1A2 gene results in the substitution of the α2(I) chain by one α1(I) chain. As th...

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Bibliographic Details
Main Authors: Andriotis, O. G., Chang, S. W., Vanleene, M., Howarth, P. H., Davies, D. E., Shefelbine, S. J., Thurner, P. J., Buehler, Markus J
Other Authors: Massachusetts Institute of Technology. Center for Materials Science and Engineering
Format: Article
Language:en_US
Published: Royal Society 2016
Online Access:http://hdl.handle.net/1721.1/101599
https://orcid.org/0000-0002-4173-9659

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