Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

Understanding how antibiotics impact bacterial metabolism may provide insight into their mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we profiled the metabolome of Escherichia coli after treatment with three different classes of bactericidal antibiotics (β-lactams...

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Bibliographic Details
Main Authors: Belenky, Peter, Ye, Jonathan D., Cohen, Nadia R., Ferrante, Thomas, Jain, Saloni, Korry, Benjamin J., Schwarz, Eric G., Walker, Graham C., Collins, James J., Porter, Caroline, Lobritz, Michael
Other Authors: Institute for Medical Engineering and Science
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101612
https://orcid.org/0000-0002-0712-3383
https://orcid.org/0000-0001-7243-8261
https://orcid.org/0000-0002-3848-8991
https://orcid.org/0000-0002-5560-8246

Internet

http://hdl.handle.net/1721.1/101612
https://orcid.org/0000-0002-0712-3383
https://orcid.org/0000-0001-7243-8261
https://orcid.org/0000-0002-3848-8991
https://orcid.org/0000-0002-5560-8246

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