Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells
Large dsRNA molecules can cause potent cytotoxic and immunostimulatory effects through the activation of pattern recognition receptors; however, synthetic versions of these molecules are mostly limited to simple sequences like poly-I:C and poly-A:U. Here we show that large RNA molecules generated by...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Oxford University Press
2016
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| Online Access: | http://hdl.handle.net/1721.1/101673 https://orcid.org/0000-0002-4031-7286 https://orcid.org/0000-0002-4954-8443 https://orcid.org/0000-0003-3988-0837 |