Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

Cancer-associated fibroblasts (CAFs) are non-cancerous cells found in solid tumors that remodel the tumor matrix and promote cancer invasion and angiogenesis. Here, we demonstrate that Cdc42EP3/BORG2 is required for the matrix remodeling, invasion, angiogenesis, and tumor-growth-promoting abilities...

Full description

Bibliographic Details
Main Authors: Calvo, Fernando, Ranftl, Romana, Hooper, Steven, Farrugia, Aaron J., Moeendarbary, Emad, Bruckbauer, Andreas, Batista, Facundo, Charras, Guillaume, Sahai, Erik
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101697
https://orcid.org/0000-0002-7019-3907

Internet

http://hdl.handle.net/1721.1/101697
https://orcid.org/0000-0002-7019-3907

Similar Items