Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression

Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression

Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo. Haptotaxis on FN gradients requires direct interaction betwee...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Oudin, Madeleine Julie, Jonas, Oliver H., Kosciuk, Tatsiana, Broye, Liliane C., Candido Guido, Bruna, Wyckoff, Jeffrey, Asokan, Sreeja B., Whittaker, Charles A., Ma, Duanduan, Cima, Michael J., Wisinski, Kari B., Keely, Patricia J., Bear, James E., Gertler, Frank, Riquelme, Daisy Noelia, Lamar, John, Langer, Robert S, Hynes, Richard O, Lauffenburger, Douglas A
Eará dahkkit: Massachusetts Institute of Technology. Department of Biological Engineering
Materiálatiipa: Artihkal
Giella:en_US
Almmustuhtton: American Association for Cancer Research 2016
Liŋkkat:http://hdl.handle.net/1721.1/101752
https://orcid.org/0000-0003-2379-6139
https://orcid.org/0000-0001-6988-4260
https://orcid.org/0000-0003-2512-2007
https://orcid.org/0000-0003-3214-4554
https://orcid.org/0000-0002-3048-7927
https://orcid.org/0000-0001-7603-8396
https://orcid.org/0000-0003-4255-0492

Interneahtta

http://hdl.handle.net/1721.1/101752
https://orcid.org/0000-0003-2379-6139
https://orcid.org/0000-0001-6988-4260
https://orcid.org/0000-0003-2512-2007
https://orcid.org/0000-0003-3214-4554
https://orcid.org/0000-0002-3048-7927
https://orcid.org/0000-0001-7603-8396
https://orcid.org/0000-0003-4255-0492

Geahča maid