Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

Generation of potent antibodies by a mutation-selection process called affinity maturation is a key component of effective immune responses. Antibodies that protect against highly mutable pathogens must neutralize diverse strains. Developing effective immunization strategies to drive their evolution...

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Bibliographic Details
Main Authors: Wang, Shenshen, Mata-Fink, Jordi, Kriegsman, Barry, Irvine, Darrell J., Eisen, Herman N., Burton, Dennis R., Kardar, Mehran, Chakraborty, Arup K., Wittrup, Karl Dane, Eisen, Herman N., Hanson, Melissa Catherine, Irvine, Darrell J, Chakraborty, Arup K
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101768
https://orcid.org/0000-0003-2398-5896
https://orcid.org/0000-0002-6064-0531
https://orcid.org/0000-0003-1268-9602
https://orcid.org/0000-0002-1112-5912

Internet

http://hdl.handle.net/1721.1/101768
https://orcid.org/0000-0003-2398-5896
https://orcid.org/0000-0002-6064-0531
https://orcid.org/0000-0003-1268-9602
https://orcid.org/0000-0002-1112-5912

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