High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis

Murine models of osteoarthritis (OA) and post-traumatic OA have been widely used to study the development and progression of these diseases using genetically engineered mouse strains along with surgical or biochemical interventions. However, due to the small size and thickness of murine cartilage, t...

Full description

Bibliographic Details
Main Authors: Gauci, Stephanie J., Frank, Eliot, Fosang, Amanda J., Ortiz, Christine, Grodzinsky, Alan J., Tavakoli Nia, Hadi, Azadi Sohi, Mojtaba, Hung, Han-Hwa K.
Other Authors: Massachusetts Institute of Technology. Center for Biomedical Engineering
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/102071
https://orcid.org/0000-0003-3511-5679
https://orcid.org/0000-0003-1970-9901
https://orcid.org/0000-0002-4942-3456