Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

The retinoblastoma tumor suppressor (pRb) protein associates with chromatin and regulates gene expression. Numerous studies have identified Rb-dependent RNA signatures, but the proteomic effects of Rb loss are largely unexplored. We acutely ablated Rb in adult mice and conducted a quantitative analy...

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Bibliographic Details
Main Authors: Nicolay, Brandon N., Danielian, Paul S., Kottakis, Filippos, Lapek, John D., Sanidas, Ioannis, Miles, Wayne O., Dehnad, Mantre, Gierut, Jessica J., Manning, Amity L., Morris, Robert, Haigis, Kevin, Bardeesy, Nabeel, Haas, Wilhelm, Dyson, Nicholas J., Lees, Jacquelineb, Tschop, Katrin, Lees, Jacqueline
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2016
Online Access:http://hdl.handle.net/1721.1/102107
https://orcid.org/0000-0001-9451-2194

Internet

http://hdl.handle.net/1721.1/102107
https://orcid.org/0000-0001-9451-2194

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