Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
The retinoblastoma tumor suppressor (pRb) protein associates with chromatin and regulates gene expression. Numerous studies have identified Rb-dependent RNA signatures, but the proteomic effects of Rb loss are largely unexplored. We acutely ablated Rb in adult mice and conducted a quantitative analy...
Main Authors: | , , , , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Cold Spring Harbor Laboratory Press
2016
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Online Access: | http://hdl.handle.net/1721.1/102107 https://orcid.org/0000-0001-9451-2194 |