Stent elution rate determines drug deposition and receptor-mediated effects

Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a mathematical framework of arterial drug distribution and receptor binding following stent elution. Model predictions that tissue content linearly...

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Bibliographic Details
Main Authors: Tzafriri, Abraham R., Groothuis, Adam, Price, G. Sylvester, Edelman, Elazer R.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/102303
https://orcid.org/0000-0002-7832-7156