Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic pla...

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Bibliographic Details
Main Authors: Tian, Di, Lindemann, Lothar, Jaeschke, Georg, Stoppel, Laura Jane, Heynen, Arnold J., Mills, Alea A., Bear, Mark
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Nature Publishing Group 2016
Online Access:http://hdl.handle.net/1721.1/102336
https://orcid.org/0000-0001-6673-4988

Internet

http://hdl.handle.net/1721.1/102336
https://orcid.org/0000-0001-6673-4988

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