The Role of Cdk5 in Neuroendocrine Thyroid Cancer

The Role of Cdk5 in Neuroendocrine Thyroid Cancer

Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer that originates from calcitonin-secreting parafollicular cells, or C cells. We found that Cdk5 and its cofactors p35 and p25 are highly expressed in human MTC and that Cdk5 activity promotes MTC proliferation. A conditional MTC mouse model...

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Bibliographic Details
Main Authors: Pozo, Karine, Castro-Rivera, Emely, Tan, Chunfeng, Plattner, Florian, Schwach, Gert, Siegl, Veronika, Meyer, Douglas, Guo, Ailan, Gundara, Justin, Mettlach, Gabriel, Richer, Edmond, Guevara, Jonathan A., Ning, Li, Gupta, Anjali, Hao, Guiyang, Tsai, Li-Huei, Sun, Xiankai, Antich, Pietro, Sidhu, Stanley, Robinson, Bruce G., Chen, Herbert, Nwariaku, Fiemu E., Pfragner, Roswitha, Richardson, James A., Bibb, James A.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/102512
https://orcid.org/0000-0003-1262-0592

Internet

http://hdl.handle.net/1721.1/102512
https://orcid.org/0000-0003-1262-0592

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