Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

Rett syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein thought to act as a global transcriptional repressor. Here we show, using an isogenic human embryonic stem cell model of RTT, that MECP2 mutant neurons display key molecular and cellular features of this disorder. Unbi...

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Bibliographic Details
Main Authors: Li, Yun, Wang, Haoyi, Muffat, Julien, Cheng, Albert W., Orlando, David A., Feldman, Danielle A., Bateup, Helen S., Gao, Qing, Hockemeyer, Dirk, Mitalipova, Maisam, Lewis, Caroline A., Sur, Mriganka, Young, Richard A., Jaenisch, Rudolf, Loven, Jakob, Vander Heiden, Matthew G., Feldman, Danielle A., Young, Richard A., Lewis, Caroline, Kwok, Show Ming
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/102529
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0001-9168-0109
https://orcid.org/0000-0003-2442-5671
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0002-6883-3805

Internet

http://hdl.handle.net/1721.1/102529
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0001-9168-0109
https://orcid.org/0000-0003-2442-5671
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0002-6883-3805

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