Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
Chronic exposure to drugs of abuse or stress regulates transcription factors, chromatin-modifying enzymes and histone post-translational modifications in discrete brain regions. Given the promiscuity of the enzymes involved, it has not yet been possible to obtain direct causal evidence to implicate...
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| অন্যান্য লেখক: | |
| বিন্যাস: | প্রবন্ধ |
| ভাষা: | en_US |
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Nature Publishing Group
2016
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| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/1721.1/102587 https://orcid.org/0000-0003-2782-2509 https://orcid.org/0000-0002-3854-5968 |
| _version_ | 1826201900766199808 |
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| author | Sun, Haosheng Shao, Ningyi Feng, Jian Mazei-Robison, Michelle Ferguson, Deveroux Knight, Scott Nievera, Christian Han, Ming-Hu Shen, Li Zhang, H Steve Zhang, Feng Nestler, Eric J Heller, Elizabeth A. Cates, Hannah M. Pena, Catherine J. Golden, Sam A. Herman, James P. Walsh, Jessica J. Gerber, Mark A. Russo, Scott J. Tamminga, Carol S. Neve, Rachael L. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Sun, Haosheng Shao, Ningyi Feng, Jian Mazei-Robison, Michelle Ferguson, Deveroux Knight, Scott Nievera, Christian Han, Ming-Hu Shen, Li Zhang, H Steve Zhang, Feng Nestler, Eric J Heller, Elizabeth A. Cates, Hannah M. Pena, Catherine J. Golden, Sam A. Herman, James P. Walsh, Jessica J. Gerber, Mark A. Russo, Scott J. Tamminga, Carol S. Neve, Rachael L. |
| author_sort | Sun, Haosheng |
| collection | MIT |
| description | Chronic exposure to drugs of abuse or stress regulates transcription factors, chromatin-modifying enzymes and histone post-translational modifications in discrete brain regions. Given the promiscuity of the enzymes involved, it has not yet been possible to obtain direct causal evidence to implicate the regulation of transcription and consequent behavioral plasticity by chromatin remodeling that occurs at a single gene. We investigated the mechanism linking chromatin dynamics to neurobiological phenomena by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo. We found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked transcriptional and behavioral responses via interactions with the endogenous transcriptional machinery. This approach allowed us to relate the epigenetic landscape at a given gene directly to regulation of its expression and to its subsequent effects on reward behavior. |
| first_indexed | 2024-09-23T11:58:39Z |
| format | Article |
| id | mit-1721.1/102587 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:58:39Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1025872022-09-27T23:14:38Z Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors Sun, Haosheng Shao, Ningyi Feng, Jian Mazei-Robison, Michelle Ferguson, Deveroux Knight, Scott Nievera, Christian Han, Ming-Hu Shen, Li Zhang, H Steve Zhang, Feng Nestler, Eric J Heller, Elizabeth A. Cates, Hannah M. Pena, Catherine J. Golden, Sam A. Herman, James P. Walsh, Jessica J. Gerber, Mark A. Russo, Scott J. Tamminga, Carol S. Neve, Rachael L. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Neve, Rachael L. Zhang, Feng Chronic exposure to drugs of abuse or stress regulates transcription factors, chromatin-modifying enzymes and histone post-translational modifications in discrete brain regions. Given the promiscuity of the enzymes involved, it has not yet been possible to obtain direct causal evidence to implicate the regulation of transcription and consequent behavioral plasticity by chromatin remodeling that occurs at a single gene. We investigated the mechanism linking chromatin dynamics to neurobiological phenomena by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo. We found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked transcriptional and behavioral responses via interactions with the endogenous transcriptional machinery. This approach allowed us to relate the epigenetic landscape at a given gene directly to regulation of its expression and to its subsequent effects on reward behavior. 2016-05-23T00:29:39Z 2016-05-23T00:29:39Z 2014-10 2014-10 Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/102587 Heller, Elizabeth A, Hannah M Cates, Catherine J Pena, Haosheng Sun, Ningyi Shao, Jian Feng, Sam A Golden, et al. “Locus-Specific Epigenetic Remodeling Controls Addiction- and Depression-Related Behaviors.” Nature Neuroscience 17, no. 12 (October 27, 2014): 1720–27. https://orcid.org/0000-0003-2782-2509 https://orcid.org/0000-0002-3854-5968 en_US http://dx.doi.org/10.1038/nn.3871 Nature Neuroscience Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Sun, Haosheng Shao, Ningyi Feng, Jian Mazei-Robison, Michelle Ferguson, Deveroux Knight, Scott Nievera, Christian Han, Ming-Hu Shen, Li Zhang, H Steve Zhang, Feng Nestler, Eric J Heller, Elizabeth A. Cates, Hannah M. Pena, Catherine J. Golden, Sam A. Herman, James P. Walsh, Jessica J. Gerber, Mark A. Russo, Scott J. Tamminga, Carol S. Neve, Rachael L. Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors |
| title | Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors |
| title_full | Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors |
| title_fullStr | Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors |
| title_full_unstemmed | Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors |
| title_short | Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors |
| title_sort | locus specific epigenetic remodeling controls addiction and depression related behaviors |
| url | http://hdl.handle.net/1721.1/102587 https://orcid.org/0000-0003-2782-2509 https://orcid.org/0000-0002-3854-5968 |
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