Cas9 Functionally Opens Chromatin

Cas9 Functionally Opens Chromatin

Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional activation by the settler transcription factor retinoic acid receptor at prev...

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Bibliographic Details
Main Authors: Barkal, Amira A., Srinivasan, Sharanya, Gifford, David K., Sherwood, Richard I., Hashimoto, Tatsunori Benjamin
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Public Library of Science 2016
Online Access:http://hdl.handle.net/1721.1/102604
https://orcid.org/0000-0003-0521-5855
https://orcid.org/0000-0003-1709-4034

Internet

http://hdl.handle.net/1721.1/102604
https://orcid.org/0000-0003-0521-5855
https://orcid.org/0000-0003-1709-4034

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