The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury

Much of the global cancer burden is associated with longstanding inflammation accompanied by release of DNA-damaging reactive oxygen and nitrogen species. Here, we report that the Mbd4 DNA glycosylase is protective in the azoxymethane/dextran sodium sulfate (AOM/DSS) mouse model of inflammation-driv...

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Bibliographic Details
Main Authors: Yu, Amy Marie, Calvo, Jennifer A., Muthupalani, Sureshkumar, Samson, Leona D
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: Impact Journals/National Center for Biotechnology Information (U.S.) 2016
Online Access:http://hdl.handle.net/1721.1/102633
https://orcid.org/0000-0002-7112-1454